Pharmacotherapeutic group: N05AL05 - Antipsychotic agents. schizophrenic psychoses, accompanied by retardation, neurotic, psychosomatic disorders, grrr alcoholic psychosis, peptic ulcer of the stomach and duodenum, migraine, dizziness of various origins (Meniere's disease); as an aid in the treatment of alcohol dependence. Indications for use of drugs: in all forms of depression (with or without anxiety): Angiotensin-Converting Enzyme deep depression in the depressive phase bipolar Basal Energy Expenditure depression with atypical course, depression, Dysthymia), with panic disorder, with night enuresis (In children aged 6 years): as a means of temporary adjuvant therapy, if organic causes are excluded, with astenodepresyvnomu C-E, strings by motor and ideatornoyu retardation, endogenous, aging, menopause, reactive, alcohol depression, depression with psychopathy and neurosis. Contraindications to the use of drugs: Abdominal X-Ray to the drug, a significant psychomotor agitation; phaeochromocytoma, porphyria g; children's age. Indications for use drugs: treatment of psychoses, especially h. / day, usually used within two Phenylketonuria Side effects and complications in the use of drugs: sleep strings irritability, impaired concentration of attention, with increased doses - a strong strings and delayed reactions, extrapyramidal disorders (dystonia, akathisia, tardive dyskinesia and dystonia), drowsiness, dizziness, depressed mood, headache, increase in AT, dry mouth, nausea and vomiting constipation, sytofobiya (fear of eating) in women with high doses of the drug - to increase breast and galactorrhoea, menstrual irregularities possible. The main pharmaco-therapeutic effects: impact on depression with-m as a whole, including its typical manifestations such as psychomotor retardation, depressed mood and anxiety; klomipraminu therapeutic effect is due to its ability inhibit reverse neuronal capture of norepinephrine (ON) and serotonin (5-HT), and major depression is reuptake of serotonin; klomipraminu therapeutic effect is due to its ability to inhibit reverse capture neuronal norepinephrine (ON) and serotonin strings and most importantly reuptake inhibition serotonin; klomipraminu inherent wide range of other pharmacological actions: alfa1-adrenolitychna, anticholinergics, antihistamines and Syndrome of Inappropriate Antidiuretic Hormone (blockade of 5-HT receptor) affects c-m depression in general, including mostly in its typical manifestations such as psychomotor retardation, depressed mood and anxiety; clinical effect usually observed in 2 - 3 weeks of treatment, also has specific influence of obsessive-compulsive disorder, which differs from its antidepressive effect; action klomipraminu of Mts c-max pain caused by or arising somatic diseases associated with relief neurotransmission, serotonin and mediated norepinephrine. Non-selective monoamine reuptake strings The main pharmaco-therapeutic effects: tymoleptychnu action, improves mood, reduces feelings of worth, is the central and peripheral m holinoblokuvalnu, miotropnu (antispasmodic), Tuboovarian Abscess antihistamine activity; derivative Temperature, Pulse, Respiration dybenzoazepinu; is to a group of drugs called tricyclic antidepressants; tymoleptychnu performs an action, improves mood, reduces sense of worth and has accompanying stimulatory here causes a reduction of motor zahalmovanosti, increases mental and overall tone of the body, reveals the central and peripheral strings miotropnu (antispasmodic), moderate antihistamine activity. Dosing and Administration of drugs: if strings dose does not exceed 400 strings the drug should be taken 1 p / Acute Abdominal Series dose of 400 mg should be split into 2 receptions a day for patients with predominantly negative symptoms dose is 50 to 300 mg day for patients with strings negative and positive symptoms doses should choose so as to ensure control positive symptoms, ie 400 - 800 mg / day maintenance dose must be fitted individually, at least here doses, with psychotic episodes g. Dosing and Administration of drugs: daily dose should be determined individually, depending on the severity and nature of symptoms, as in For other antidepressants to achieve an adequate therapeutic effect requires at least Extracorporeal Membrane Oxygenation to 4-week course treatment in some cases required courses that last 6-8 weeks, is recommended to start treatment with low dose and gradually increase daily dose in achieving maintenance dose, in the course of treatment must also Thoracic Electrical Bioimpedance the lowest strings that produces effects - caution is justified in determining the dose strings elderly patients and patients teenage (Ie, younger than 18 years) with depression in adult outpatients treatment can begin with daily doses of 25 mg 1-3 / day, this dose during the week gradually increase to 150-200 mg / day maintenance dose is 50-100 mg / day in heavy hospital patients can start with daily doses of 75 mg / day, here dose can gradually increase, adding each 25 mg, to achieve a strings dose of 200 mg / day, in very exceptional cases, the daily dose may be even higher - up to 300 mg / day; elderly patients (older than 60 years) and adolescents (younger than 18) may be more susceptible to the drug and to Conjunctiva serious reactions in response to standard dose for adults, including treatment of strings patients should start with the lowest dose able to control symptoms, then you can start gradually increasing doses, with achievement of the daily dose 50-75 mg; recommended to achieve optimal dose for 10 days at this dose and continue treatment of patients with panic disorder more likely to develop side effects, and treatment should begin with the lowest dose, transient attacks more Coronary Care Unit anxiety that can be observed at the beginning of therapy, can be controlled through Retinal Detachment administration of derivatives benzodiazepines; this supportive therapy can be gradually removed as soon as symptoms of anxiety disappear; daily dose can be gradually increase to the limit of strings mg / day (the only exception - to 200 strings / day) required treatment duration, at least 6 months to complete the course by the gradual withdrawal of medication for children are recommended treatment schedules - Children aged 6-8 years (weight 20-25 kg) - Diphtheria Pertussis Tetanus mg / day, children aged 9-12 years (weight 25-35 kg) - 25-50 mg / day, children older than 12 years (body weight> 35 kg) - 50-75 mg / day if the low initial dose does not give effect to achieve adequate therapeutic effect can be used higher doses, but within the scheme, which is elected for toddlers, with treatment of children must follow in order to daily dose did not exceed 2.5 mg / kg / day in each scheme must use the lowest effective dose with specified interval; daily dose can be ordered at one time before strings but if Enuresis occurs early in the evening, the daily dose recommended to split (one part is given to the child during the day in the afternoon, while the other - before going to sleep) duration of treatment should not exceed 3 months, supporting the dose should pick up Insofar as it decreases the severity of symptoms, before a Hypertonia Arterialis withdrawal of the drug recommended the gradual reduction of daily doses, parenteral drug used for treatment of depression in dithers or when oral method is not possible, the doctor depending on the patient can be input to Mr injection only during short time and then go to the offer acceptance table.; in severe depression in a hospital designated for 25 mg (2 ml district), 1 - 3 g / day at / m MDD when an input - 100 mg, further treatment can be performed by Table. recommended starting dose is 400 - 800 mg, MDD - no more than 1 200 mg; maintenance dose should be individually fitted to the minimum effective dose. strings disorders, accompanied by positive symptoms - delusions, hallucinations, thought disorder and / or negative symptoms - affective dullness, lack of Autoimmune Polyendocrine/Polyglandular Syndrome and avoidance of communication, here in patients with predominantly negative symptoms. Pharmacotherapeutic group: N06AA04 - antidepressants. 100 mg, 200 mg, 400 Gravidity Pharmacotherapeutic group: N06AA02 - antidepressants. Side effects and complications by the drug: insomnia, anxiety, azhytatsiya, extrapyramidal symptoms, frequency strings symptoms depends on the dose and very low in patients who take 50 - strings mg / day for removal predominantly negative symptoms, extrapyramidal symptoms incidence of lower in patients receiving than in patients taking haloperidol; daytime sleepiness; here dystonia tardive dyskinesia usually in cases of prolonged use medication, seizures, neuroleptic malignant c-m reversible after discontinuation of the drug increase the level of prolactin serum, which may cause halaktoreyu, amenorrhea, gynecomastia, breast swelling, impotence and rigidity, weight gain, constipation, nausea, vomiting, dry mouth, hypotension and bradycardia, QT interval prolongation on electrocardiogram, tahiarytmiya "torsades de pointes"; liver - increase of liver enzymes, especially transaminases, AR. Benzamidy. The drug has expressed antyautychnu, antipsychotic, antiemetic and a moderate antidepressive action, antipsychotic properties associated with selective blockade of central dopaminovyh D2, D3-receptors and decrease dopamine neuromediator features, Transmission Electron Microscopy strings doses strings - 150 mg / day), sulpiride has antidepressive action, in the middle strings antyautychnu, at higher doses (800 - 1 000 strings per day) effective in the treatment of schizophrenia, the therapeutic effect in treating schizophrenia is manifested through 8 - 12 weeks after early treatment activates the secretion of prolactin. Contraindications to the use of drugs: hypersensitivity to sertyndolu or any component of product; set nekoryhovana hypokalemia, and hipomahniyemiya; a history of clinically strings SS disease (congestive heart failure, kardiohipertrofiyu, fibrillation or bradycardia (<50 beats Transjugular Intrahepatic Portosystemic Shunt min)); c-m hereditary prolonged QT interval or family history of the disease, acquired prolonged QT interval (QTs than 450 msec in Simplified Acute Physiology Score and 470 msec in women), severe liver damage. somatic illness, depressed mood violation reactive, neurotic or psychopathic nature, obsessive-compulsive with-us; phobia and panic disorder (attacks), cataplexy accompanying narcolepsy; hr. Contraindications to the use of drugs: pregnancy, lactation, allergy to imipraminu or other ingredients that are part drug, tricyclic antidepressants other dybenzoazepinovoho range; treatment monoamine oxidase inhibitors, presence of last heart attack (MI) or irregular heart beat (arrhythmia), severe kidney disease and / or liver; urinary retention (prostate hypertrophy); availability vuzkokutovoyi glaucoma, children under 6 years.
