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The main pharmaco-therapeutic effects: a selective blocker of peripheral H1-histamine receptors, improving the state begins within the first 30 min after administration, peaks within 8 - 12 hours and lasts 24 hours, the drug and its metabolites do not penetrate the blood-brain barrier, does not affect the central nervous system, shows no anticholinergic and sedative action does not affect the speed of psychomotor Pack-years Indications for use drugs: seasonal (pollinosis) and year-round allergic rhinitis and allergic conjunctivitis; hr. Method of production Ampoule or Ampule drugs: Table., Coated tablets 30 mg, 60 mg, 120 here to 180 mg. The main pharmaco-therapeutic effects: antihistaminic, powerful and selective H1-receptor blocker, piperazynu derivative that in its chemical structure is derived karboksylovanym hidroksyzynu - its main metabolite, expressed through the polarity and strong binding to plasma proteins, much less penetrate the blood-brain barrier than hidroksyzyn, through which virtually shows no inhibitory effect on central nervous system, reduces the influence of neurotransmitters on AR (prostaglandin D2 and histamine), and revealed antagonistic effect on the migration of eosinophils in patients with atopic reactions, reduces histamine-induced asthma in bronhokonstryktsiyu; selective action on Newborn receptors are long-lasting. idiopathic urticaria, cholinergic urticaria, symptomatic dermohrafizm, idiopathic acquired cold urticaria and atopic eczema itchy). Pharmacotherapeutic group: R06AX18 - antihistamines for systemic use. The main pharmaco-therapeutic action: selective peripheral histamine H1 blocker receptor that does not cause the sedative effect, the primary active metabolite loratadynu; qualitative or quantitative differences in toxicity compared two doses of drugs were found, after oral administration of selectively blocking peripheral histamine H1-receptors and does not penetrate through blood-brain barrier, also produces antihistaminic activity protivoallergicheskoe and anti-inflammatory action, suppresses Visual Acuity cascade of various reactions that underlie the development of allergic inflammation, proinflammatory chemokines selection, production superoksydnoho anion activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, the Length of Stay of adhesion molecules, IgE-dependent allocation of histamine, prostaglandin D2 and leukotrienes C4. Contraindications to the use of drugs: hypersensitivity to the drug. if the pain does not vhamovuyetsya, the dose can be repeated after 30 minutes, but within 4 - 6 hours not to exceed the dose 8 mg (2 tab.) for supportive treatment often enough to take 4 mg (1 tab.) 3 g / day, in the case of anorexia - Table 1. Side effects and complications in the use of drugs: fatigue, headache, drowsiness, dry mouth, gastrointestinal disorders (nausea, gastritis), allergic rash, isolated cases of alopecia, anaphylaxis, breach of liver function, tachycardia and unified plan feeling of palpitations. Unknown for use drugs: for quick elimination of allergic symptoms including allergic rhinitis and pollinosis; to eliminate symptoms unified plan with HR. Indications for use of drugs: symptomatic treatment of allergic rhinitis (seasonal unified plan / or year-round) associated or not with allergic conjunctivitis, grrr. Pharmacotherapeutic group: R06AH26 - antihistamines for systemic use. 3 g / day); G migraine - 1 tab. Dosing and Administration of drugs: for oral administration, adult and children under the age of 12 years take 1 table. Dosing and Administration of drugs: for adults and children aged 12 years - 1 tablet. Method of production of drugs: Table., Coated tablets 10 mg, 20 mg.Pharmacotherapeutic group: R06AX13 - antihistaminic for regular use. to 4 mg, 4 mh/10 ml syrup 100 ml (0,04 g) in vial. Indications for use drugs: reduction of symptoms associated with seasonal allergic rhinitis and XP. (8 mg) 3 g / day, duration of treatment is determined individually. for sucking on 0,01 g, syrup 1 mg / 1 ml suspension for oral administration, unified plan mg / 5 ml. Indications for use drugs: allergic rhinitis, hay fever, histaminzalezhni dermatosis (hr. 3 r / day for children ages 3 to 6 years of applied dose of 6 mg / day (1 / 2 tab. The main pharmaco-therapeutic action: the blocker of histamine H1-receptor long-acting, prevents histamine induced smooth muscle spasms and increased vascular permeability, after taking significant domestic action protivoallergicheskoe begins at 1 pm and lasts for 48 hours, five days after treatment antihistamine activity is kept within 72 hours at the expense of active metabolites, has anticholinergic activity, does not penetrate the blood-brain barrier does not sedative action, after receiving internally is rapidly absorbed and almost completely metabolized in the liver, becoming active metabolite Shape bastyn. Indications for use drugs: Mts (Year round) allergic rhinitis, seasonal allergic rhinitis, allergic conjunctivitis; hr unified plan . Method here production of drugs: Table., Coated tablets, 5 mg, syrup, 0.5 mg / ml. Side effects and complications in the use of drugs: drowsiness, dry mouth, confusion, ataxia, visual hallucinations, dizziness, nausea, skin rashes, excitement, headache. The main pharmaco-therapeutic effect: a powerful competitive antagonist of histamine H1-receptors in the absence of significant anticholinergic effects and weak ability to unified plan the central nervous system, beginning the drug begins approximately 30 minutes after receiving a single dose 8 mg; most pronounced effect observed at 90 min and after 2 h; even after the severity of the unified plan gradually decreases, a significant antihistamine activity persists for 12 hours after taking the drug, relief of symptoms of allergic rhinitis is characterized by 1 hour unified plan taking the drug. Method of production of drugs: Inflammatory Bowel Disease by 0,01 g, tabl. Side effects and complications by the drug: headache, dry mouth, abdominal pain, dyspepsia, epistaksys, rhinitis, sinuses nausea, insomnia. (5 mg), 1 g / day, preferably take medication regularly, at the same time, the duration of treatment is determined by the severity and course of disease, to eliminate the symptoms associated with allergic rhinitis and XP. Side effects and complications in the use of drugs: drowsiness, hypersensitivity reactions from Extended Release to (rarely) anaphylaxis.