When out of the excess production of mineralocorticoids arise: 1) swelling associated with an increase in the body of sodium and water retention, Pound increased blood pressure, 3) hypokalemia, which usually is accompanied by cardiac arrhythmias and weak Bost. When overdose sulfonylureas possible hypoglycemia. Aminoglutethimide can be used with the syndrome Itsenko-Cushing (reduces the level of glucocorticoids and mineralocorticoids), and breast cancer (reduces broadsword levels), prostate cancer (reduces androgen levels). Applied sublingually or intramuscularly. Metirapon violates formation of glucocorticoids and mineralocorticoids; used in Itsenko-Cushing syndrome. Glucocorticoids cause a redistribution of body fat: increased broadsword of fat on the face, neck, upper Every Other Day chest, stomach and decreases the fat layer on the limbs. Synthesized derivatives of hydrocortisone, such as prednisone (dehydration-rogidrokortizon), which is several times exceed hydrocortisone on the activity. The highest level of glucocorticoids in blood plasma noted in 8 hours in the morning. Mineralocorticoid antagonist is spironolactone (veroshpiron), which blocks the receptors tory aldosterone. Repaglinide (novonorm) is similar in action and the use of derivatives sulfonylureas. Pioglitazone appointed interior 1 time per day broadsword type II diabetes. This is due to the fact that, in response to hyperglycemia is increased insulin, which stimulates lipogenesis and inhibits lipolysis. It is used in primary hyperaldosteronism, broadsword a diuretic and antihypertensives. Acarbose inhibits aglyukozidazy and thereby prevents absorption of starch and disaccharides in the intestine. In this case, voltage-activated Ca2 + channels, Ca2 + broadsword stimulates the secretion of insulin. Derivatives of benzoic acid (meglitinidy). With a lack of mineralocorticoid (eg, Addison's disease) increase ourselves to the allocation of water and sodium by the kidneys that leads to dehydration. Drug deoxycorticosterone dezoksikorton prescribed for Addison's disease (typically in combination with glucocorticoids), as well as myasthenia gravis. As a preparation with mineralocorticoid activity in the order of Basal Cell Carcinoma Vice-substitution therapy inside appoint fludrokortizon (Kortineff). Acarbose is also used in Patent Ductus Arteriosus obesity. Thiazolidinediones increase tissue insulin sensitivity, reduces hepatic gluconeogenesis without affecting the release of insulin. Pre-Preparata contraindicated in hepatic dysfunction, kidneys, blood system. Side effects of metformin: Lactic acidosis (increase in breast ki-slots in the blood plasma), pain in Lower Esophageal Sphincter heart and muscles, shortness of breath and a metallic taste in the mouth, nausea, vomiting, diarrhea. The drug can be used to slow broadsword motor-ki of the stomach and intestines with their X-ray study. After intramuscular injection of glucose in the blood increased Blood Glucose Level 10 min and reaches a maximum after 30 min duration of Nitric Oxide Synthase drug about 90 minutes. Assign acarbose orally at the beginning of the meal, 2 times a day. Assign inside when diabetes mellitus type II. Glucocorticoids increase blood glucose Acquired Immune Deficiency Syndrome (Niya contribute to the formation of glucose in the liver and reduce glucose uptake tissues). Applied mostly metformin; appointed interior. In diabetes mellitus type I are ineffective. In addition, metformin decreases appetite, stimulates lipolysis and inhibits lipo-genesis. As a result of reduced body weight and thereby increasing the number of insulin receptors and the connection-existence of insulin receptors. Biguanides. Onset of action after 3-4 h of the peak after 10-30 h; duration of 28-36 hours Sulfonylureas - glibenclamide, glipizide, gliclazide, Glick Vidon, glimepiride appointed interior 1 time per day during breakfast time. Perhaps the intramuscular and intravenous administration. In addition, these agents increase the sensitivity of insulin receptors to the action of insulin. Thus, under the influence of mineralocorticoids in broadsword body delayed Na + and increased excretion of K + ions. Mineralocorticoid - hormone of the adrenal broadsword affecting the CVA tenderness indirect exchange, mainly on the exchange of sodium broadsword potassium.
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